Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes

US7229987B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Jochen Ammenn · Hamburg, DE
• James Gillig · Indianapolis, US
• Lawrence Joseph Heinz · Pittsboro, US
• Philip Arthur Hipskind · New Palestine, US
• Michael Dean Kinnick · Indianapolis, US
• Yen-Shi Lai · Chapel Hill, US
• John Michael Morin, Jr. · Brownsburg, US
• James A. Nixon · Indianapolis, US
• Carsten Ott · Bad Segeberg, DE
• Kenneth A. Savin · New York, US
• Theo Schotten · Winsen (Luhe), DE
• Lawrence John Slieker · Carmel, US
• Nancy June Snyder · Charlottesville, US
• Michael Alan Robertson · Indianapolis, US

Key dates

• Filing date: May 6, 2003
• Grant date: Jun 12, 2007
• Expiry date: Jun 7, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.