Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

US7230008B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Richard Jiao · Collingswood, US
• Gabor Butora · Bound Brook, US
• Stephen D. Goble · Edison, US
• Deodialsingh Guiadeen · Linden, US
• Sander G. Mills · Scotch Plains, US
• Gregori J. Morriello · Dover, US
• Alexander Pasternak · Brookline, US
• Cheng Tang · East Brunswick Township, US
• Lihu Yang · Edison, US
• Changyou Zhou · Princeton, US
• Shankaran Kothandaraman · Plain City, US
• Christopher Moyes · Westfield, US

Key dates

• Filing date: Aug 20, 2004
• Grant date: Jun 12, 2007
• Expiry date: Oct 11, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/4375
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to methods for treating, preventing, ameliorating, controlling or reducing the risk of an inflammatory or immunoregulatory disorder or disease, which method comprises the administration to a patient of an effective amount of the compound of formula I:(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.