11β-hydroxysteroid dehydrogenase inhibitors

US7230020B2 · kind B2 · utility

Assignee

• Sterix Limited · GB

Inventors

• Nigel Vicker · Slough, GB
• Su Xiangdong · Bath, GB
• Dharshini Ganeshapillai · Felton, GB
• Atul Purohit · Slough, GB
• Michael John Reed · London, GB
• Barry Victor Lloyd Potter · Slough, GB

Key dates

• Filing date: Oct 22, 2004
• Grant date: Jun 12, 2007
• Expiry date: Feb 17, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound having Formula IR1—Z—R2Formula Iwherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is —X—Y—L— or —Y—X—L— wherein either X is selected from —S(═O)(═O)— and —C(═O)—; and Y is —NR3—; or X is selected from —S(═O)(═O)— and —S—, and Y is —C(R4)(R5)—; L is an optional linker; and R3, R4 and R5 are each independently selected from H and hydrocarbyl; and wherein when R2 comprises the following structural moietywherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R1—C(═O)—NR3—L—R2; R1—S(═O)(═O)—C(R4)(R5)—L—R2; R1—S—C(R4)(R5)—L—R2; R1—NR3—S(═O)(═O)—L—R2; R1—NR3—C(═O)—L—R2; R1—C(R4)(R5)—S(═O)(═O)—L—R2; and R1—C(R4)(R5)—S—L—R2.