Site-selective acyl transfer
US7230072B2 · kind B2 · utility
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Key dates
| Filing date | May 7, 2001 |
| Grant date | Jun 12, 2007 |
| Priority date | — |
| Expiry date | May 22, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/1077
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for site-selective acyl transfer in amidation of folded polypeptides and proteins based on the use of a chemical structure element comprising an imidazole function, such as histidine, in position i flanked by at least one functional group to be amidated, such as lysinc, in position i+3+4k. where K is an integer equal to or higher than −1, or in position i−4−4n, wherein n is an integer equal to or higher than 0, and at least one activating group, such as serine, in position i+4+4n or i−3−4n, respectively.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.