Multiplex analysis for high throughput discrimination of GPCR agonists and antagonists
US7232659B1 · kind B1 · utility
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Key dates
| Filing date | Feb 4, 2004 |
| Grant date | Jun 19, 2007 |
| Priority date | — |
| Expiry date | Jan 17, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/13
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates generally to molecular assemblies, more particularly to an assay for the detection of G-protein coupled receptor (GPCR) molecular assemblies and bead-based detection of ligand-GPCR complexes and to methods for identifying compounds as agonists, partial agonists or antagonists of the binding of G-protein coupled receptors to G-protein and for use of these compounds in the treatment of conditions or disease states in a mammalian subject or patient, including humans, where G-protein coupled receptor binding to G-protein is implicated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.