Compositions and methods for modulating NH2-terminal Jun Kinase activity

US7232897B2 · kind B2 · utility

Assignee

• Harvard University, President and Fellows of Harvard College · US

Inventors

• Gokhan S. Hotamisligil · Cambridge, US
• Michael Karin · Village of La Jolla, US
• Lufen Chang · Monterey Park, US

Key dates

• Filing date: Apr 24, 2002
• Grant date: Jun 19, 2007
• Expiry date: Apr 24, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/675
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods used to modulate a NH2-terminal Jun Kinase activity. These compositions and methods can be employed to regulate metabolic disorders associated with, for example, insulin such as diabetes. The reduction in NH2-terminal Jun Kinase activity can lead to the reduction in weight and improve insulin sensitivity.