Pyridine derivatives

US7232909B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Toshiki Murata · Nara, JP
• Masaomi Umeda · Nara, JP
• Sachiko Sakakibara · Nara, JP
• Takashi Yoshiro · Nara, JP
• Hiroki Sato · Nara, JP
• Tsutomu Masuda · Amagasaki, JP
• Yuji Koriyama · Kusatsu, JP
• Mitsuiyuki Shimada · Meerbusch, DE
• Takuya Shintani · Kyoto, JP
• Hiroshi Kadono · Kasai, JP
• Timothy B. Lowinger · Carlisle, US
• Karl Ziegelbauer · Wuppertal, DE
• Kinji Fuchikami · Kyoto, JP
• Hiroshi Komura · Nara, JP

Key dates

• Filing date: Sep 30, 2005
• Grant date: Jun 19, 2007
• Expiry date: Oct 18, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention is to provide a process for producing 2-amino-4,6-disubstituted nicotinic acid ester analogs and salts thereof, comprising the reaction shown by the following scheme. The ester analogs can be prepared in one pot, and in good yield by using tertiary alkyl cyanoacetate. Furthermore, the method is useful for preparing derivatives of various analogs of the ester, e.g. alkyl substituted and aryl substituted analogs.