Optical sampling interface system for in vivo measurement of tissue
US7233816B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 12, 2004 |
| Grant date | Jun 19, 2007 |
| Priority date | — |
| Expiry date | Aug 12, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2562/146
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.