Methods of using 2-methoxyestradiol of high purity
US7235540B2 · kind B2 · utility
2Cited by
60References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 26, 2005 |
| Grant date | Jun 26, 2007 |
| Priority date | — |
| Expiry date | Sep 26, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J1/007
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.