Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US7235648B1 · kind B1 · utility
4Cited by
28References
60Claims
0Family size
Assignee
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Key dates
| Filing date | Feb 26, 1999 |
| Grant date | Jun 26, 2007 |
| Priority date | — |
| Expiry date | Feb 26, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/395
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.