Anthranilamides and methods of their use

US7235690B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Joachim Brendel · Bad Vilbel, DE
• Bernard Pirard · Frankfurt, DE
• Stefan Peukert · Frankfurt am Main, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Horst Hemmerle · Lorsch, DE

Key dates

• Filing date: Apr 26, 2002
• Grant date: Jun 26, 2007
• Expiry date: Oct 3, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is related to anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations containing them. The compounds act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. The compounds are therefore suitable for use as novel antiarrhythmic agents for the treatment and prophylaxis of atrial arrhythmias (e.g., atrial fibrillation (AF) or atrial flutter).