Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
US7235695B2 · kind B2 · utility
2Cited by
45References
26Claims
0Family size
Inventors
Key dates
| Filing date | Aug 16, 2005 |
| Grant date | Jun 26, 2007 |
| Priority date | — |
| Expiry date | Aug 16, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.