Patent · US Expired

Laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis

US7235781B2 · kind B2 · utility

13Cited by

2References

22Claims

0Family size

Assignee

Bruker Daltonik GmbH · DE

Inventors

Andreas Haase · Park City, US
Markus Kayser · Bremen, DE
Jens Höhndorf · Bremen, DE
Armin Holle · Oyten, DE

Key dates

Filing date	Sep 14, 2005
Grant date	Jun 26, 2007
Priority date	—
Expiry date	Sep 14, 2025

Classification

Technology area (CPC H)Electricity
CPC primaryH01S3/08022
WIPO fieldOptics
WIPO sectorInstruments

Abstract

The invention relates to a laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis. The invention consists in providing a laser system which generates a spatially modulated intensity distribution with intensity spots on the sample, which significantly improves the quality and the robustness of the mass spectrometric analysis compared with a spatially homogeneous intensity distribution and, in particular, improves the ionization efficiency and, for a time-of-flight mass spectrometer with axial injection, the mass resolution and the signal-to-noise ratio.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.