System and method for the large scale labeling of compounds with radiohalogens
US7238338B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 20, 2002 |
| Grant date | Jul 3, 2007 |
| Priority date | — |
| Expiry date | Jun 14, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/534
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods for manufacturing radiohalogen-labeled steroids, nucleosides, nucleotides and proteins, for example, pyrimidines and proteins. Methods according to the example embodiments specific to pyrimidines includes dissolving a halogenated pyrimidine to obtain an initial solution, adding bis(tributyltin) and triphenylphosphine palladium to produce a catalyzed solution, heating the catalyzed solution under conditions sufficient to induce a reaction that produces an intermediate solution including a stannylated pyrimidine compound, removing substantially all of the first solvent from the intermediate solution to obtain an intermediate composition, purifying the resulting solution to obtain a purified composition including a stannylated pyrimidine, reacting the stannylated pyrimidine compound with a radiohalogen in a buffered reaction mixture to produce the radiohalogenated pyrimidine, adding an antioxidant and extracting the radiohalogenated pyrimidine from the reaction mixture. The extracted radiohalogenated pyrimidine(s) may be utilized in forming diagnostic and/or therapeutic products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.