Phage-display peptides as novel antimicrobial agents against Haemophilus influenzae

US7238669B2 · kind B2 · utility

Assignee

• The Curators of the University of Missouri · US

Inventors

• Sharon Bishop-Hurley · Yeppoon, AU
• Francis J. Schmidt · Columbia, US
• Arnold L. Smith · Oskaloosa, US

Key dates

• Filing date: Sep 4, 2003
• Grant date: Jul 3, 2007
• Expiry date: Mar 16, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Whole cell phage-display techniques were used to identify several peptides that bound preferentially to a non-typeable strain of Haemophilus influenzae. These peptides were able to inhibit growth of both H. influenzae and Staphylococcal aureus. Thus, methods for treating bacterial infections, alone or in combination with traditional antibiotics, are envisioned.