Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them

US7238684B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Ingemar Starke · Gothenburg, SE
• Mikael Dahlstrom · Timrå, SE
• Mats Peter Nordberg · Göteborg, SE
• Suzanne Alenfalk · Hultsfred, SE
• Andreas Wallberg · Timrå, SE
• Stig Jonas Bostrom · Timrå, SE

Key dates

• Filing date: Apr 23, 2003
• Grant date: Jul 3, 2007
• Expiry date: Aug 6, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): wherein Rv, R1, R2, Rx, Ry, R3, R4, R5, R6, Rz and v are as defined within; pharmaceutically acceptable salts, solvates, solvates or such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.