Preparation of cabergoline
US7238810B2 · kind B2 · utility
0Cited by
10References
68Claims
0Family size
Inventors
Key dates
| Filing date | Apr 7, 2005 |
| Grant date | Jul 3, 2007 |
| Priority date | — |
| Expiry date | Nov 18, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D457/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and 4-fluorotoluene or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a method for preparing cabergoline Form I comprising dissolving cabergoline in 4-fluorotoluene or 1,3,5-trimethylbenzene and recovering the cabergoline Form 1 polymorph. Cabergoline Form I can then be obtained from the solution, suitably by direct crystallization of Form I or by recovery of a solvate which can be converted to Form I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.