Method for producing novel β-lactam antibiotic from protoplast fusion strain
US7241588B2 · kind B2 · utility
2Cited by
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4Claims
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Key dates
| Filing date | Sep 9, 2003 |
| Grant date | Jul 10, 2007 |
| Priority date | — |
| Expiry date | Dec 13, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P35/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a method for producing a novel β-lactam antibiotic from a protoplast fusion strain. The method is to fermentatively culture the protoplast fusion strain of Penicillium chrysogenum and Cephalosporium acremonium. The ferment filtrate is isolated, lyophilized, and extracted by acetone or acetone/methanol. The extract is concentrated by decompression, and then analyzed by preparation type HPLC to isolate the active antibiotic compound.
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