Urotensin-II agonists and antagonists

US7241737B2 · kind B2 · utility

Assignees

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR
• The Administrators of the Tulane Educational Fund · US

Inventors

• David H. Coy · New Orleans, US
• Wojciech Rossowski · Kenner, US
• John E. Taylor · Upton, US

Key dates

• Filing date: Oct 19, 2001
• Grant date: Jul 10, 2007
• Expiry date: Oct 19, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a novel class of cyclic polypeptides of the formula: (R1)a-AA1-cyclo[AA2-AA3-AA4-AA5-AA6-Cys]-AA7-R2, pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification, which inhibit the effects of urotensin-II and are useful for treating a variety of diseases and/or conditions characterized by an excess of urotensin-II including ischaemic heart disease, congestive heart failure, portal hypertension, variceal bleeding, hypotension, angina pectoris, myocardial infarction, ulcers, anxiety, schizophrenia, manic depression, delirium, dementia, mental retardation and/or dyskinesias.