Purine analogs having HSP90-inhibiting activity

US7241890B2 · kind B2 · utility

Assignee

• Conforma Therapeutics Corporation · US

Inventors

• Srinivas Rao Kasibhatla · San Diego, US
• Kevin Hong · San Diego, US
• Lin Zhang · Beijing, CN
• Marco Biamonte · San Diego, US
• Marcus F. Boehm · San Diego, US
• Jiandong Shi · San Diego, US
• Junhua Fan · San Diego, US

Key dates

• Filing date: Oct 30, 2002
• Grant date: Jul 10, 2007
• Expiry date: Oct 30, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel purine compounds of Formula I.and tautomers, pharmaceutically acceptable salts, and prodrugs thereof, wherein X is S, S(O), or S(O)2; and O is selected from alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl, and heterocyclic, all optionally substituted, are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.