Patent · US Expired

Soluble complex comprising a retroviral surface glycoprotein

US7244575B2 · kind B2 · utility

1Cited by

7References

26Claims

0Family size

Assignee

Roche Diagnostics GMBH · DE

Inventors

Christian Scholz · Penzberg, DE
Herbert Andres · Penzberg, DE
Elke Faatz · Huglfing, DE
Alfred Engel · Tutzing, DE
Dorothea Sizmann · Iffeldorf, DE

Key dates

Filing date	Mar 24, 2005
Grant date	Jul 17, 2007
Priority date	—
Expiry date	Apr 2, 2025

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/2821
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein-(or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.