Glucose dehydrogenase
US7244581B2 · kind B2 · utility
3Cited by
1References
7Claims
0Family size
Inventor
Key dates
| Filing date | Jun 13, 2003 |
| Grant date | Jul 17, 2007 |
| Priority date | — |
| Expiry date | Jun 13, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/904
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed is a modified glucose dehydrogenase having pyrroloquinoline quinone as a coenzyme, wherein one or more amino acid residues in a region of amino acid 349-377 of water-soluble PQQGDH derived from Acinetobacter calcoaceticus is replaced with other amino acid residues and has an inhibition constant (Ksi) of 200 mM or more. The modified water-soluble PQQGDH of the invention can be utilized for measuring glucose levels in the presence of high concentrations of glucose because of the low substrate inhibition by glucose.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.