Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates

US7244762B2 · kind B2 · utility

Assignee

• Sterix Limited · GB

Inventors

• Alexander Hillisch · Solingen, DE
• Olaf Peters · Bad Tabarz, DE
• Christian Gege · Ehingen (Donau), DE
• Gerhard Siemeister · Berlin, DE
• Eberhard Unger · Cospeda, DE
• Bernd Menzenbach · Jena, DE

Key dates

• Filing date: Feb 19, 2004
• Grant date: Jul 17, 2007
• Expiry date: Feb 19, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for treating tumor diseases, which can be influenced positively by the inhibition of tubulin polymerization. The compounds according to the invention are distinguished by a D-homosubstitution. They have a special action with respect to tubulin polymerization inhibition and can be used, for example, for treating prostate cancer