Process for preparing benzhydrylthioacetamide
US7244865B2 · kind B2 · utility
1Cited by
22References
32Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 23, 2004 |
| Grant date | Jul 17, 2007 |
| Priority date | — |
| Expiry date | Jul 8, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C319/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetamide is prepared in high yield and purity by the reaction of a haloacetamide with the reaction product of thiourea and benzhydrol in aqueous solution. The reaction employing the haloacetamide is conducted in a solvent comprising water and an organic solvent such as dimethylformamide having dissolved therein a basic salt such as potassium carbonate. The resulting benzhydrylthioacetamide can be oxidized to provide the pharmaceutical modafinil.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.