Classifying cancers

US7247426B2 · kind B2 · utility

Assignee

• AGILENT TECHNOLOGIES, INC. · US

Inventors

• Zohar Yakhini · Palo Alto, US
• Michael L. Bittner · Rockville, US
• Jeff Trent · Rockville, US
• Amir Ben-Dor · Kfar Sava, IL
• Paul Meltzer · Rockville, US
• Yidong Chen · Rockville, US
• Ashani Weeraratna · Dunkirk, US
• Yuan Jiang · Gaithersburg, US
• Nick Sampas · San Jose, US
• Edward R. Dougherty · College Station, US

Key dates

• Filing date: Aug 2, 2001
• Grant date: Jul 24, 2007
• Expiry date: Apr 22, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/136
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The overexpression of certain marker genes including Wnt5a has been found useful in the identification of more aggressive forms of malignant melanoma. Therefore, the overexpression of these genes in tumor samples of malignant melanoma may be useful in the diagnosis, profiling, and treatment of patients suffering from this disease. Inhibitors of Wnt5a activity may be useful in the treatment of aggressive forms of malignant melanoma. Inhibition of Wnt5a activity may be effected by any method including anti-sense therapy, gene therapy, and pharmaceutical intervention.