Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment

US7247642B2 · kind B2 · utility

Assignee

• Wockhardt Limited · IN

Inventors

• Mahesh Vithalbhai Patel · Aurangabad, IN
• Shivkumar Agarwal · Aurangabad, IN
• Sreenivas Kandepu · Hyderabad, IN
• Nitin Shetty · Kalyan-Dombivli, IN
• Dilip J. Upadhyay · Thane, IN
• Nishith Chaturvedi · Sayla, IN
• Abraham Thomas · Jamkhed, IN
• Noel De Souza · Mumbai, IN
• Habil Khorakiwala · Mumbai, IN

Key dates

• Filing date: May 8, 2000
• Grant date: Jul 24, 2007
• Expiry date: May 8, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(+)-isomers, and to pharmaceutical compositions comprising the S(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof.