Phosphitylation process
US7247720B2 · kind B2 · utility
2Cited by
2References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 8, 2003 |
| Grant date | Jul 24, 2007 |
| Priority date | — |
| Expiry date | Jan 16, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the phosphitylation of an alcohol or thiol with a phosphitylation agent in the presence of an activator is provided. The activator has the formula:wherein p is 0 or an integer from 1 to 4 and R for each occurrence is a substituent. Preferably X7 is O and p is 0. The activator is commonly employed as a salt complex with an organic base. Preferred alcohols or thiols include nucleosides and oligonucleotides. The process is particularly suited for the synthesis of phosphoramidites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.