Method of identifying inhibitors of DHODH

US7247736B2 · kind B2 · utility

Assignee

• 4SC AG · DE

Inventors

• Johann Leban · Planegg, DE
• Bernd Kramer · Aachen, DE
• Roland BAUMGARTNER · Birkenfeld, DE
• Katharina Aulinger-Fuchs · Schwanau, DE
• Stefan Tasler · Hanerau-Hademarschen, DE

Key dates

• Filing date: Nov 10, 2004
• Grant date: Jul 24, 2007
• Expiry date: Jan 25, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.