Methods for the synthesis of astaxanthin

US7247752B2 · kind B2 · utility

Assignee

• Cardax Pharmaceuticals, Inc. · US

Inventors

• Samuel Lockwood · Lake Linden, US
• Peng Cho Tang · Moraga, US
• Geoff Nadolski · Kaaawa, US
• Henry Jackson · Honolulu, US
• Zhiqiang Fang · 流花街道, CN
• Yishu Du · Shanghai, CN
• Min Yang · Vernon Hills, US
• William B. Geiss · Athens, US
• Richard Williams · Newbury Park, US
• David Burdick · Guilderland, US

Key dates

• Filing date: Oct 3, 2005
• Grant date: Jul 24, 2007
• Expiry date: Oct 3, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.