Fluorescence reader based on anti-resonant waveguide excitation

US7248361B2 · kind B2 · utility

Assignee

• Palo Alto Research Center Incorporated · US

Inventors

• Peter Kiesel · Palo Alto, US
• Oliver Wolst · Walzbachtal, DE
• Michael A. Kneissl · Berlin, DE
• Huangpin B. Hsieh · Mountain View, US
• Oliver Schmidt · Palo Alto, US

Key dates

• Filing date: Dec 22, 2005
• Grant date: Jul 24, 2007
• Expiry date: Dec 22, 2025

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2021/6493
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A sample detection system including an anti-resonant waveguide, including a sample having a first index of refraction, a top layer and a substrate surrounding the sample, where the top layer has a second index of refraction, and the substrate has a third index of refraction. The second index of refraction, and the third index of refraction are both greater than the first index of refraction. A detection device of the system includes a low power light source used to direct light into the sample and generate an anti-resonant optical mode in the sample, and an analyzing system to detect the interaction of the light propagating in the sample.