Assay for measuring IκB kinase activity and identifying IκB kinase modulators
US7250268B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Jul 14, 2004 |
| Grant date | Jul 31, 2007 |
| Priority date | — |
| Expiry date | Mar 22, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a functional assay for IκB kinase (IKK), the proteasome and ubiquitin ligase. Cells expressing an IκB-beta-lactamase fusion protein are used to screen for inhibitors of IKK, the proteasome and ubiquitin ligase. Inhibitors identified through the inventive assay are useful in the treatment of NF-κB disorders, such as immune and inflammatory disorders. The present invention also includes cell lines useful in assays of the invention, compounds identified by assays of the invention, compositions including such compounds and methods for the treatment of disease states.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.