Method and means for producing high titer, safe, recombinant lentivirus vectors
US7250299B1 · kind B1 · utility
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15References
18Claims
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Key dates
| Filing date | Apr 26, 2000 |
| Grant date | Jul 31, 2007 |
| Priority date | — |
| Expiry date | Apr 26, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.