Avermectin derivatives

US7250402B2 · kind B2 · utility

Assignee

• The Kitasato Institute · JP

Inventors

• Satoshi Omura · Tokyo, JP
• Kenichiro Nagai · Tokyo, JP
• Toshiaki Sunazuka · Chiba, JP

Key dates

• Filing date: Nov 29, 2004
• Grant date: Jul 31, 2007
• Expiry date: Nov 29, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound represented by the general formula (I) or a salt thereof:whereinrepresents —CH═CH—, —CH2—CH2— or the like,between R1 and the carbon atom at 4′-position represents a single bond or a double bond,between R2 and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) whenrepresents —CH═CH— or —CH2—CH2—, andbetween R1 and the carbon atom at 4′-position represents a double bond, R1 represents ═C(R11)(R12) (wherein R11 represents a lower alkyl group or the like and R12 represents a hydrogen atom or the like) or the like, and R2 represents a hydroxyl group or the like, or R2 may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) whenrepresents —CH═CH— or —CH2—CH2—, andbetween R1 and the carbon atom at 4′-position represents a single bond, R1 represents —OCH(R1a)(R1b) (wherein R1a represents a lower alkyl or the like and R1b represents a hydrogen atom or the like) or the like, and R2 represents a hydroxyl group or the like.