Patent · US Expired

Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility

US7250408B2 · kind B2 · utility

0Cited by

3References

10Claims

0Family size

Assignee

Bayer Schering Pharma AG · DE

Inventors

Ulrich Bothe · Berlin, DE
Gerd Schubert · Jena, DE
Guenter Kaufmann · Jena, DE
Lothar Sobek · Jena, DE
Vladimir Patchev · Jena, DE
Alexander Hillisch · Solingen, DE

Key dates

Filing date	Dec 12, 2003
Grant date	Jul 31, 2007
Priority date	—
Expiry date	Apr 24, 2025

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J1/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The novel glucocorticoid receptor antagonists are 11β-substituted steroid compounds of formula (I):wherein R1 denotes a methyl group, a methoxy group, or an ethoxy group; wherein R2 denotes a tert.-butyl group, a 1-hydroxy-1-methylethyl group, a 1-methoxy-1-methylethyl group, an ethyl isocrotonate group, or a substituted phenyl group. The method of treating an individual suffering from glucocorticoid-mediated hypogonadism, sexual dysfunctions, and/or infertility includes administering a daily dosage consisting of an effective amount of one of these 11β-substituted steroid compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.