C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes
US7250413B2 · kind B2 · utility
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2References
18Claims
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Assignee
Inventors
Key dates
| Filing date | Apr 26, 2005 |
| Grant date | Jul 31, 2007 |
| Priority date | — |
| Expiry date | Oct 18, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the current invention relate to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. More specifically, compounds of the current invention relate to C-25 carbamate derivatives of rifamycin having another functional group or pharmacophore covalently attached to this position through a carbamate linkage. The resulting compounds exert their antimicrobial activity through a dual-function mechanism and therefore exhibit reduced frequency of resistance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.