Azacytosine analogs and derivatives
US7250416B2 · kind B2 · utility
14Cited by
6References
43Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 11, 2005 |
| Grant date | Jul 31, 2007 |
| Priority date | — |
| Expiry date | Mar 11, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/048
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds and compositions of azacytosine analogs and derivatives are provided. In one aspect of the invention, analogs or derivatives of decitabine and azacitidine are provided with modification at the 4- and 6-position of the triazine ring, at the 1′–6′ position of the ribose ring, or combinations thereof. Methods of synthesizing and manufacturing these analogs and derivatives are also provided. These compounds can be formulated into pharmaceutical compositions that can be used for treating any disease that is sensitive to the treatment with decitabine or azacitidine, such as hematological disorders and cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.