Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
US7250421B2 · kind B2 · utility
5Cited by
6References
28Claims
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Key dates
| Filing date | Jan 31, 2005 |
| Grant date | Jul 31, 2007 |
| Priority date | — |
| Expiry date | Mar 11, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65616
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.