Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
US7250494B2 · kind B2 · utility
11Cited by
31References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 20, 2002 |
| Grant date | Jul 31, 2007 |
| Priority date | — |
| Expiry date | May 22, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.