Synthesis process for 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid
US7250529B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Sep 16, 2005 |
| Grant date | Jul 31, 2007 |
| Priority date | — |
| Expiry date | Jan 26, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A highly advantageous process for the preparation of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid or a salt thereof is described. The process comprises subjecting 1-acetyl 3-hydroxyadamantane to liquid phase oxidation with permanganate to produce 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid or a salt thereof, with acidification to form the free acid when appropriate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.