Molecular torches and their use under denaturing conditions
US7252947B2 · kind B2 · utility
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47Claims
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Key dates
| Filing date | Jan 27, 2005 |
| Grant date | Aug 7, 2007 |
| Priority date | — |
| Expiry date | Dec 24, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6818
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention features “molecular torches” and the use of molecular torches for detecting the presence of a target nucleic acid sequence. Molecular torches contain a target binding domain, a target closing domain, and a joining region. The target binding domain is biased towards the target sequence such that the target binding domain forms a more stable hybrid with the target sequence than with the target closing domain under the same hybridization conditions. The joining region facilitates the formation or maintenance of a closed torch.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.