Patent · US Expired

Compounds and methods for modulating cell-adhesion mediated drug resistance

US7253149B2 · kind B2 · utility

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1References
14Claims
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Assignee

Inventors

Key dates

Filing dateOct 29, 2004
Grant dateAug 7, 2007
Priority date—
Expiry dateNov 10, 2024

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K14/7055
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Peptides and methods of their use for inhibiting drug and radiation-therapy resistance in cancerous cells in which efficacy of chemotherapy and/or radiotherapy of a patient is enhanced by administration of an effective amount of a peptide that inhibits cell adhesion mediated drug resistance (CAM-DR). Preferably, the peptide comprises D-amino acids having the sequence:kmviywkag (RZ-3)or is a variant or modified version thereof. The peptide is preferably administered to the patient prior to chemotherapy and/or radiation therapy. Inhibition of cell adhesion mediated drug resistance (CAM-DR) by RZ-3 in multiple myeloma cells is disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.