Substituted 1-benzyl-4-substituted piperazine analogues

US7253168B2 · kind B2 · utility

Assignee

• Neurogen Corporation · US

Inventors

• Alan Hutchison · Madison, US
• Bertrand L. Chenard · Waterford, US
• James G. Tarrant · Hamden, US
• Guiying Li · Branford, US
• Manuka Ghosh · Madison, US
• George P. Luke · Clinton, US
• John M. Peterson · Madison, US
• Wallace Pringle · Guilford, US
• Mary-Margaret O'Donnell · Shelton, US
• Kyungae Lee · Newton, US
• Linda M. Gustavson · Guilford, US
• Dario Doller · Wallingford, US

Key dates

• Filing date: Apr 6, 2005
• Grant date: Aug 7, 2007
• Expiry date: Apr 6, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula I are provided, in which variables are as described herein:Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).