Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof

US7253341B2 · kind B2 · utility

Assignees

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL
• Fulcrum SP Ltd. · IL

Inventors

• Wangxia Wang · 甘垛镇, CN
• Dan Pelah · Omer, IL
• Tal Alegrand · Gdera, IL
• Yehonathan Pouny · Givat Shmuel, IL
• Ira Marton · Rehovot, IL
• Amnon Wolf · Herzliya, IL
• Oded Shoseyov · Karmei Yosef, IL
• Arie Altman · Rehovot, IL

Key dates

• Filing date: Sep 4, 2002
• Grant date: Aug 7, 2007
• Expiry date: Jan 8, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/35
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating macromolecules such as proteins; fusion proteins including SPs; nucleic acid constructs encoding the fusion proteins; and their uses in a variety of methods and applications.