Enterobacteriaceae strains with an attenuated aspA gene for the fermentative production of amino acids

US7256021B2 · kind B2 · utility

Assignee

• Degussa AG · DE

Inventor

• Thomas Hermann · Bielefeld, DE

Key dates

• Filing date: Jul 3, 2002
• Grant date: Aug 14, 2007
• Expiry date: Sep 6, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P13/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the preparation of L-amino acids, especially L-lysine, L-valine, L-homoserine and L-threonine, by fermenting a microorganism of the genus Escherichia which has a mutation or deletion in the gene encoding aspartate ammonium lyase (aspA). This mutation results in the loss of aspA enzymatic activity in the microorganism