Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7256219B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Mar 14, 2002 |
| Grant date | Aug 14, 2007 |
| Priority date | — |
| Expiry date | Sep 24, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C205/45
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I:wherein Ar and R6-R10 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.