Method and apparatus for performing second harmonic optical coherence tomography

US7256894B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Zhongping Chen · Irvine, US
• Yi Sik Jang · Beijing, CN

Key dates

• Filing date: Oct 20, 2004
• Grant date: Aug 14, 2007
• Expiry date: Sep 18, 2025

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N21/65
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention is an apparatus and method for second harmonic optical coherence tomography of a sample comprising a laser coupled to an interferometer which has a reference arm and in a sample arm. A nonlinear crystal in the reference arm generates a second harmonic reference signal. The sample typically backscatters some second harmonic light into the sample arm. A broadband beam splitter optically coupled to the reference arm and sample arm combines the signals from the reference arm and sample arm into interference fringes and a dichroic beam splitter splits the interference fringes into a fundamental and second harmonic interference signal. A detector is optically coupled to the dichroic beam splitter detects interference fringes from which both an OCT and second harmonic OCT image can be constructed using a conventional data processor.