Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
US7258854B2 · kind B2 · utility
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Key dates
| Filing date | Jul 30, 2002 |
| Grant date | Aug 21, 2007 |
| Priority date | — |
| Expiry date | May 21, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.