Rage-related methods for treating inflammation

US7258857B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• David M. Stern · Great Neck, US
• Kevan C. Herold · Rowayton, US
• Shi Du Yan · New York, US
• Ann Marie Schmidt · Franklin Lakes, US
• Ira Lamster · Morristown, US

Key dates

• Filing date: Jun 1, 2001
• Grant date: Aug 21, 2007
• Expiry date: Sep 29, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a method for treating inflammation in a subject which comprises administering to the subject soluble receptor for advanced glycation endproduct (sRAGE) in an amount effective to inhibit binding of advanced glycation endproducts (AGEs) to RAGE thereby treating inflammation in the subject. The present invention also provides for a method for treating inflammation in a subject which comprises administering to the subject an agent in an amount effective to inhibit the interaction between receptor for advanced glycation endproduct (RAGE) and its ligand thereby treating inflammation in the subject.