TNF-derived peptides for use in treating oedema
US7258861B2 · kind B2 · utility
3Cited by
1References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 6, 2002 |
| Grant date | Aug 21, 2007 |
| Priority date | — |
| Expiry date | Sep 4, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/525
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is based on the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-α) can efficiently be used to treat oedema. More specifically, the present invention relates to the usage of peptides derived from the region of human TNF-α from Ser100 to Glu116 to treat pulmonary oedema. For example, the circularized peptide having amino acid sequence CGQRETPEGAEAKPWYC is shown to be very efficient in inducing oedema resorption.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.