Mechanically activated channel blocker
US7259145B2 · kind B2 · utility
5Cited by
2References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 7, 2005 |
| Grant date | Aug 21, 2007 |
| Priority date | — |
| Expiry date | Oct 10, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/858
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a peptide of SEQ ID NO:1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alterations in mechanical stress.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.